Cytoskeletal Fluidization and Resolidification are Required for Reorientation of Endothelial Cells

Vascular endothelial cells are subjected to routine mechanical stretch. In response, cellular microstructures rearrange locally as the cell body realigns globally [1–5]. These responses, which underlie the vital functions of the endothelium, are often explained in terms of upstream mechanosensing and downstream cell signaling [2–5].