Atherosclerosis is the main cause of cardiovascular disease and is characterized by plaque formation, with lipid accumulation in the arterial wall, covered by a fibrous cap. Rupture of such a cap is the main underlying cause of sudden coronary deaths and strokes. Cap rupture occurs when the mechanical stress in the cap exceeds local cap strength. Accurate determination of cap stresses might therefore play an important role in the prediction of cap rupture. An important determinant of plaque deformation and cap stress is the mechanical behaviour of the diseased plaque components, of which little is known. The aim of this study is to determine material properties of atherosclerotic plaques using a mixed experimental-numerical approach. Plaque deformation as measured ex-vivo with magnetic resonance imaging (MRI) will be matched with computed deformations based on the measured plaque geometry.
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Plaque Deformation in Atherosclerotic Porcine Arteries
L. Speelman,
L. Speelman
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
ICIN Netherlands Heart Institute, Utrecht, Utrecht, The Netherlands
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M. Goffi,
M. Goffi
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
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A. C. Akyildiz,
A. C. Akyildiz
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
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H. Nieuwstadt,
H. Nieuwstadt
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
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K. Van der Heiden,
K. Van der Heiden
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
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A. van der Steen,
A. van der Steen
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
ICIN Netherlands Heart Institute, Utrecht, Utrecht, The Netherlands
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J. Wentzel,
J. Wentzel
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
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F. Gijsen
F. Gijsen
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
ICIN Netherlands Heart Institute, Utrecht, Utrecht, The Netherlands
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L. Speelman
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
ICIN Netherlands Heart Institute, Utrecht, Utrecht, The Netherlands
M. Goffi
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
A. C. Akyildiz
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
H. Nieuwstadt
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
K. Van der Heiden
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
A. van der Steen
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
ICIN Netherlands Heart Institute, Utrecht, Utrecht, The Netherlands
J. Wentzel
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
F. Gijsen
Erasmus MC, Rotterdam, Zuid Holland, The Netherlands
ICIN Netherlands Heart Institute, Utrecht, Utrecht, The Netherlands
Paper No:
SBC2012-80521, pp. 17-18; 2 pages
Published Online:
July 19, 2013
Citation
Speelman, L, Goffi, M, Akyildiz, AC, Nieuwstadt, H, Van der Heiden, K, van der Steen, A, Wentzel, J, & Gijsen, F. "Plaque Deformation in Atherosclerotic Porcine Arteries." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 17-18. ASME. https://doi.org/10.1115/SBC2012-80521
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