Hemodynamics have been linked to the genesis and progress of vascular disease in humans and animals1. Disturbed flow patterns such as stagnant flow or flow reversal lead to low or oscillating wall shear stress (WSS). Several in-vivo studies have correlated these types of WSS with disease formation1, 2. The desire to find correlations between markers of vascular disease and mechanical stimuli and because of their easier availability has led to an increasing number of animal model studies. The mouse, in particular, is a commonly used animal for investigating vascular disease formation and progression. Suo et al., were one of the first to relate findings on the molecular level with WSS1. They found increased VCAM and ICAM expression in areas of low WSS. More recently Hoi et al.2, have shown a correlation between atherosclerotic plaque development and hemodynamic parameters such as low time averaged wall shear stress (TAWSS) and Oscillatory Shear Index (OSI).
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Hemodynamics of the Rat Aortic Arch Available to Purchase
David S. Molony,
David S. Molony
Georgia Institute of Technology, Atlanta, GA
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Andrew Nencka,
Andrew Nencka
Medical College of Wisconsin, Milwaukee, WI
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Zhixin Li,
Zhixin Li
Medical College of Wisconsin, Milwaukee, WI
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Ming Zhao,
Ming Zhao
Northwestern University, Evanston, IL
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Don P. Giddens
Don P. Giddens
Georgia Institute of Technology, Atlanta, GA
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David S. Molony
Georgia Institute of Technology, Atlanta, GA
Andrew Nencka
Medical College of Wisconsin, Milwaukee, WI
Zhixin Li
Medical College of Wisconsin, Milwaukee, WI
Ming Zhao
Northwestern University, Evanston, IL
Don P. Giddens
Georgia Institute of Technology, Atlanta, GA
Paper No:
SBC2012-80371, pp. 1271-1272; 2 pages
Published Online:
July 19, 2013
Citation
Molony, DS, Nencka, A, Li, Z, Zhao, M, & Giddens, DP. "Hemodynamics of the Rat Aortic Arch." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 1271-1272. ASME. https://doi.org/10.1115/SBC2012-80371
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