Biological and anatomical changes of intervertebral disc (IVD) degeneration frequently occur in the nucleus pulposus (NP) [1]. Changes in NP matrix composition coincide with the loss of a distinct notochord derived cell population [2],[3], which may have the potential to generate or maintain a functional NP-like matrix. Immature NP cells reside in an environment rich in laminin and express specific laminin-binding receptors [4],[5]. Additionally, NP cells attach in higher numbers to laminins as compared to cells isolated from other regions of the IVD [6]. Our initial work demonstrated that matrix protein and stiffness modulate NP cell-cell interactions upon surfaces [7], with results that suggest soft, laminin-functionalized hydrogels may be useful for promoting an NP-like cell phenotype.
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Injectable and Photocrosslinkable Laminin Functionalized Biomaterials for Intervertebral Disc Regeneration
Aubrey T. Francisco,
Aubrey T. Francisco
Duke University, Durham, NC
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Robert J. Mancino,
Robert J. Mancino
Duke University, Durham, NC
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Claire G. Jeong,
Claire G. Jeong
Duke University, Durham, NC
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Isaac O. Karikari,
Isaac O. Karikari
Duke University Medical Center, Durham, NC
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Robby D. Bowles,
Robby D. Bowles
Duke University, Durham, NC
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Stephen L. Craig,
Stephen L. Craig
Duke University, Durham, NC
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Lori A. Setton
Lori A. Setton
Duke University, Durham, NC
Duke University Medical Center, Durham, NC
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Aubrey T. Francisco
Duke University, Durham, NC
Robert J. Mancino
Duke University, Durham, NC
Claire G. Jeong
Duke University, Durham, NC
Isaac O. Karikari
Duke University Medical Center, Durham, NC
Robby D. Bowles
Duke University, Durham, NC
Stephen L. Craig
Duke University, Durham, NC
Lori A. Setton
Duke University, Durham, NC
Duke University Medical Center, Durham, NC
Paper No:
SBC2012-80660, pp. 1145-1146; 2 pages
Published Online:
July 19, 2013
Citation
Francisco, AT, Mancino, RJ, Jeong, CG, Karikari, IO, Bowles, RD, Craig, SL, & Setton, LA. "Injectable and Photocrosslinkable Laminin Functionalized Biomaterials for Intervertebral Disc Regeneration." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 1145-1146. ASME. https://doi.org/10.1115/SBC2012-80660
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