Osteoarthritis often results from degenerative changes induced by trauma such as joint impact injuries sustained during athletics, combat, or motor vehicle accidents. Articular cartilage, avascular in nature, relies of synovial nutrition [1] and lacks sufficient regenerative capabilities [2]. Acute cartilage injuries have been shown to induce cell death [3, 4, 5], leading to reduced chondrocyte density and degenerative changes to the cartilage matrix composition; over time the tissue becomes compromised and loses its ability to maintain and restore itself. It has been demonstrated, that mechanical loading can affect local perfusion and diffusion through the matrix thereby altering the flow of nutrients and metabolites [2, 6]. Furthermore, mechanical loading modulates the chondrocyte biosynthesis of extracellular matrix that is required in the cartilage repair process. In this study, a two part in-vitro porcine knee model was utilized to investigate articular cartilage response immediately following a single impact injury under cyclic mechanical loading conditions.
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Mechanical Loading Reduces Chondrocyte Death After Single Impact Trauma: Porcine Knee Model Available to Purchase
Lauren L. Vernon,
Lauren L. Vernon
University of Miami, Coral Gables, FL
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David G. Wilensky,
David G. Wilensky
University of Miami Miller School of Medicine, Miami, FL
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Chong Wang,
Chong Wang
University of Miami, Coral Gables, FL
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Lee D. Kaplan,
Lee D. Kaplan
University of Miami, Coral Gables, FL
University of Miami Miller School of Medicine, Miami, FL
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Chun-Yuh C. Huang
Chun-Yuh C. Huang
University of Miami, Coral Gables, FL
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Lauren L. Vernon
University of Miami, Coral Gables, FL
David G. Wilensky
University of Miami Miller School of Medicine, Miami, FL
Chong Wang
University of Miami, Coral Gables, FL
Lee D. Kaplan
University of Miami, Coral Gables, FL
University of Miami Miller School of Medicine, Miami, FL
Chun-Yuh C. Huang
University of Miami, Coral Gables, FL
Paper No:
SBC2012-80833, pp. 1027-1028; 2 pages
Published Online:
July 19, 2013
Citation
Vernon, LL, Wilensky, DG, Wang, C, Kaplan, LD, & Huang, CC. "Mechanical Loading Reduces Chondrocyte Death After Single Impact Trauma: Porcine Knee Model." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 1027-1028. ASME. https://doi.org/10.1115/SBC2012-80833
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