The poor ability of articular cartilage to repair following disease and injury makes the tissue a key target for reparative and regenerative medicine strategies. It has been shown that human knee joint resides under hypoxic conditions. Oxygen tension in healthy human synovium is between 7 and 11% and in articular cartilage may therefore be as low as 1–2.5% .
- Bioengineering Division
Enhancing the Mechanical Properties of Articular Cartilage Through Enzyme-Mediated Collagen Crosslinking as Regulated by Low Oxygen Tension
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Makris, EA, Hu, J, & Athanasiou, KA. "Enhancing the Mechanical Properties of Articular Cartilage Through Enzyme-Mediated Collagen Crosslinking as Regulated by Low Oxygen Tension." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 1021-1022. ASME. https://doi.org/10.1115/SBC2012-80603
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