It has been established that in order to accurately model a knee joint a reasonable approximation of the soft tissues present is necessary1. Models which include these soft tissue structures are able to better reproduce joint kinematics, loading, and analyze the impact of damage and pathological joint behavior1. Simulating the behavior of these tissues requires either a detailed understanding of materials properties that can be implemented via finite element models or the production of an empirical model that can be implemented inside other model frameworks2,3. This study explores the application of multibody (MB) modeling techniques in an attempt to capture the flexible behavior of biological tissues inside of a rigid body mechanics software, MD ADAMS (MSC software, Santa Ana, California), by tuning the performance to experimental data using design of experiments (DOE).

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