The Role of Nonmuscle Myosin IIA Regulation in Platelet Forces Using Microposts and Multiphysics Modeling Available to Purchase

A multi-physics model has been developed that closely matches with the biochemical regulation of platelet forces. The model is based on measurements of platelet forces using arrays of microposts. Different concentrations of thrombin or myosin inhibitors were added to the platelets to reduce their forces on the posts. The platelet forces obtained from the model have good agreement with those measured in the inhibition studies.