High prevalence of osteoarthritis and poor intrinsic healing capacity of articular cartilage create a demand for cell-based strategies for cartilage repair. It is possible to tissue engineer cartilage with almost native proteoglycan content, but collagen reaches only 15% to 35% of the native content. Also its natural structural organization is not reproduced. These drawbacks contribute to its insufficient load-bearing properties.
- Bioengineering Division
Agarose Concentration and TGF-B3 Supplementation Influence Matrix Deposition in Engineered Cartilage Constructs
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Kock, LM, van Donkelaar, CC, & Ito, K. "Agarose Concentration and TGF-B3 Supplementation Influence Matrix Deposition in Engineered Cartilage Constructs." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 879-880. ASME. https://doi.org/10.1115/SBC2011-53160
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