Mechanical stimuli are important to maintenance of homeostasis in many connective tissues including tendons and ligaments. Application of cyclic tensile loading in a physiological range has been demonstrated to possess anabolic and anti-catabolic effects on tenocyte metabolism [1,2], whereas the loading falling outside the range induced upregulations of tenocyte catabolism [3]. One of mechanotransduction signaling pathways of tenocytes is mediated via cytoskeletal elements [4]. It has been demonstrated that cytoskeletal tension within tenocytes regulated anabolic and catabolic gene expressions in a reciprocal manner [4]. However, the precise relationship between cell metabolism and internal tension within cytoskeletons has not been studied.

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