Soft tissues are highly heterogeneous materials comprised of water, proteins, and many types of cells. This composite configuration results in a large mismatch in index of refraction between tissue constituents, creating a high-scattering medium in the visible and near-infrared range. “Tissue optical clearing” can increase light transmission through these tissues, potentially improving both optical diagnostic and therapeutic procedures [1]. Dehydration has been shown to be a mechanism of optical clearing, and previous work has investigated mechanical loading as a method of creating reversible localized water displacement in skin using novel mechanical tissue optical clearing devices (TOCDs) [2]. In addition to potentially enhancing established light-based procedures, the principles of TOCD operation may provide a platform for a novel diagnostic tool capable of utilizing many different measurement types simultaneously.
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Multidomain Modeling of Spatial Distributions of Tissue Optical Properties During Indentation: Mechanical Tissue Optical Clearing Devices as Diagnostic Tools
William C. Vogt,
William C. Vogt
Virginia Tech-Wake Forest University, Blacksburg, VA
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Alondra Izquierdo-Roman,
Alondra Izquierdo-Roman
Virginia Tech-Wake Forest University, Blacksburg, VA
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Christopher G. Rylander
Christopher G. Rylander
Virginia Tech-Wake Forest University, Blacksburg, VA
Virginia Tech, Blacksburg, VA
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William C. Vogt
Virginia Tech-Wake Forest University, Blacksburg, VA
Alondra Izquierdo-Roman
Virginia Tech-Wake Forest University, Blacksburg, VA
Christopher G. Rylander
Virginia Tech-Wake Forest University, Blacksburg, VA
Virginia Tech, Blacksburg, VA
Paper No:
SBC2011-53923, pp. 759-760; 2 pages
Published Online:
July 17, 2013
Citation
Vogt, WC, Izquierdo-Roman, A, & Rylander, CG. "Multidomain Modeling of Spatial Distributions of Tissue Optical Properties During Indentation: Mechanical Tissue Optical Clearing Devices as Diagnostic Tools." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 759-760. ASME. https://doi.org/10.1115/SBC2011-53923
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