Topical microbicides, the next generation prevention tool for HIV and other sexually transmitted pathogens, hold great promise if the target vaginal or rectal epithelium is coated effectively. A microbicide consists of an active ingredient within a polymeric delivery vehicle (e.g. polymeric liquid or ‘gel’). Most research in the field of microbicides has been limited to the development of an active ingredient and many microbicidal trails have failed in the past. Thus, there is a need to design a delivery vehicle that optimizes the efficacy of a microbicidal agent. The effectiveness of the gel depends on the gel’s rheological properties as well as the vaginal tissue properties, vaginal geometry, and external forces like gravity. A good design must take these factors in to consideration and a better understanding of the gel’s flow behavior over the epithelium is important before proceeding with clinical trials.
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Mathematical Simulation and Parametric Study of Flow of a Microbicidal Gel Between Elastic Boundaries Available to Purchase
Sunil Karri,
Sunil Karri
University of Kansas, Lawrence, KS
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Sarah L. Kieweg
Sarah L. Kieweg
University of Kansas, Lawrence, KS
Search for other works by this author on:
Sunil Karri
University of Kansas, Lawrence, KS
Sarah L. Kieweg
University of Kansas, Lawrence, KS
Paper No:
SBC2011-53719, pp. 739-740; 2 pages
Published Online:
July 17, 2013
Citation
Karri, S, & Kieweg, SL. "Mathematical Simulation and Parametric Study of Flow of a Microbicidal Gel Between Elastic Boundaries." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 739-740. ASME. https://doi.org/10.1115/SBC2011-53719
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