Vulnerable plaques are inflamed, active, and growing lesions which are prone to complications such as rupture, luminal and mural thrombosis, intraplaque hemorrhage, and rapid progression to stenosis. Despite major advances in the prevention and treatment of this disease, it remains the leading cause of morbidity and mortality worldwide, accounting for 30% of all deaths globally [1]. The importance of stress/strain distribution is now well recognized in vascular pathophysiology, specifically in the mechanisms of plaque rupture. Finite element modeling (FEM) and advanced fluid structure interaction (FSI) studies can better characterize coronary stenosis coupling constitutive equations. Mechanical factors such as stress concentrations within a plaque (material fatigue), lesion characteristic (location, size, and composition), and flow patterns are involved in rupture of plaques. Assessment of local mechanical characteristics caused by plaque structure is important for identifying vulnerable plaques and may improve final estimation of the risk for coronary syndrome.
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Influence of Microcalcifications on Stress Development Within a Vulnerable Plaque’s Cap
Ze’ev Aronis,
Ze’ev Aronis
Tel-Aviv University, Tel-Aviv, Israel
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Erez Kanka,
Erez Kanka
Tel-Aviv University, Tel-Aviv, Israel
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Eyass Massarwa,
Eyass Massarwa
Tel-Aviv University, Tel-Aviv, Israel
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Rami Haj-Ali,
Rami Haj-Ali
Tel-Aviv University, Tel-Aviv, Israel
Georgia Institute of Technology, Atlanta, GA
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Shmuel Einav
Shmuel Einav
Tel-Aviv University, Tel-Aviv, Israel
Stony Brook University, Stony Brook, NY
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Ze’ev Aronis
Tel-Aviv University, Tel-Aviv, Israel
Erez Kanka
Tel-Aviv University, Tel-Aviv, Israel
Eyass Massarwa
Tel-Aviv University, Tel-Aviv, Israel
Rami Haj-Ali
Tel-Aviv University, Tel-Aviv, Israel
Georgia Institute of Technology, Atlanta, GA
Shmuel Einav
Tel-Aviv University, Tel-Aviv, Israel
Stony Brook University, Stony Brook, NY
Paper No:
SBC2011-53197, pp. 719-720; 2 pages
Published Online:
July 17, 2013
Citation
Aronis, Z, Kanka, E, Massarwa, E, Haj-Ali, R, & Einav, S. "Influence of Microcalcifications on Stress Development Within a Vulnerable Plaque’s Cap." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 719-720. ASME. https://doi.org/10.1115/SBC2011-53197
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