Forming the palmar roof of the carpal tunnel, the transverse carpal ligament (TCL) continues to be the surgical target for carpal tunnel release which aims to relieve the symptoms of patients with carpal tunnel syndrome. However, the surgical procedures may cause several biomechanical and anatomical problems for the carpal tunnel [1]. Therefore, an alternative, aimed at preserving the TCL, might alleviate patients’ post-operative complications. Using a geometrical model, Li et al. showed that the cross-sectional area of the carpal tunnel can be effectively increased by TCL elongation [2]. Theoretically, stiffness reduction could facilitate a ligament’s capability to elongate. Past studies have shown that the utilization of the collagenase enzyme altered the mechanical properties of a soft tissue [3, 4]. It also has been used to treat Dupuytren’s Contracture [5] because collagenase breaks the peptide bonds within collagen fibers [6]. The usage of collagenase could effectively reduce the stiffness of the TCL allowing for the ligament to elongate and for the median nerve to decompress. Thus, the purpose of our study is to determine the effect of collagenase on the stiffness of the TCL. We hypothesize that the stiffness of the ligament will progressively decrease due to the enzymatic effect of collagenase.
Skip Nav Destination
ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Stiffness of the Transverse Carpal Ligament Under the Influence of Collagenase
Ryan K. Prantil,
Ryan K. Prantil
Cleveland Clinic, Cleveland, OH
University of Pittsburgh, Pittsburgh, PA
Search for other works by this author on:
Tracy A. Mondello,
Tracy A. Mondello
Cleveland Clinic, Cleveland, OH
Search for other works by this author on:
Khurram Pervaiz,
Khurram Pervaiz
Cleveland Clinic, Cleveland, OH
Search for other works by this author on:
Savio L-Y. Woo,
Savio L-Y. Woo
University of Pittsburgh, Pittsburgh, PA
Search for other works by this author on:
Zong-Ming Li
Zong-Ming Li
Cleveland Clinic, Cleveland, OH
Search for other works by this author on:
Ryan K. Prantil
Cleveland Clinic, Cleveland, OH
University of Pittsburgh, Pittsburgh, PA
Tracy A. Mondello
Cleveland Clinic, Cleveland, OH
Suk H. Yu
Cleveland Clinic, Cleveland, OH
Khurram Pervaiz
Cleveland Clinic, Cleveland, OH
Savio L-Y. Woo
University of Pittsburgh, Pittsburgh, PA
Zong-Ming Li
Cleveland Clinic, Cleveland, OH
Paper No:
SBC2011-53284, pp. 677-678; 2 pages
Published Online:
July 17, 2013
Citation
Prantil, RK, Mondello, TA, Yu, SH, Pervaiz, K, Woo, SL, & Li, Z. "Stiffness of the Transverse Carpal Ligament Under the Influence of Collagenase." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 677-678. ASME. https://doi.org/10.1115/SBC2011-53284
Download citation file:
4
Views
Related Proceedings Papers
Related Articles
Determination of Optimal Graft Lengths for Posterior Cruciate Ligament Reconstruction—A Theoretical Analysis
J Biomech Eng (April,2003)
Does Graft Construct Lengthening at the Fixations Cause an Increase in Anterior Laxity Following Anterior Cruciate Ligament Reconstruction in vivo?
J Biomech Eng (August,2010)
Deformation-Dependent Enzyme Mechanokinetic Cleavage of Type I Collagen
J Biomech Eng (May,2009)
Related Chapters
Novel and Efficient Mathematical and Computational Methods for the Analysis and Architecting of Ultralight Cellular Materials and their Macrostructural Responses
Advances in Computers and Information in Engineering Research, Volume 2
Mechanical Effect Analysis of Interaction between Tunnel Support Structure and Surrounding Rock
Geological Engineering: Proceedings of the 1 st International Conference (ICGE 2007)
An Extensometer for Soft Material Strain Measurement
Nontraditional Methods of Sensing Stress, Strain, and Damage in Materials and Structures