Pelvic organ prolapse (POP) is a multifactorial disorder, characterized by the descent of the pelvic organs into the vaginal canal. POP is associated with decreased quality of life, and even depression, yet 50% of women over the age of fifty are living with this disorder. The estimated direct cost for POP surgeries is over one billion dollars annually, in the United States alone. This rather exorbitant figure includes the cost of surgery performed for symptom management, but does not include strategies which address the underlying cause of the disorder. It is not surprising then, that within a few years over 10% of repairs will require a second procedure. Thus, more studies are needed to understand the pathophysiology of POP.

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