Correlation of Local Mechanical Environment to Mechanically Induced Tissue Phenotype During Altered Bone Fracture Healing

Numerous studies have demonstrated that mechanical factors affect the healing process of skeletal tissues and can either enhance or hinder repair of orthopaedic injuries. Several mechanobiological theories have been proposed that relate specific mechanical stimuli to patterns of skeletal tissue differentiation^1,2,3. However, rigorous tests of these theories have been difficult to carry out because few experimental data are available on local stress and strain magnitudes induced by mechanical stimulation of skeletal tissues in vivo.