Delivering growth factors to the site of injury using a coated suture delivery method has been investigated recently as a means to augment tissue repair [1]. This is a practical approach for growth factor delivery, as sutures are the method of choice for most orthopaedic surgeons for soft tissue repairs. One advantage of growth factor-coated sutures in tendon repair is the potential to accelerate healing in vivo, thereby improving the outcome of the repair. In particular, platelet-derived growth factor-BB (PDGF-BB) is a well characterized wound healing protein known to be chemotactic and mitogenic for cells of mesenchymal origin, including tenocytes, and has been shown to improve healing when applied to animal models of tendon injury [2,3]. The aim of this study was to compare the quality of the tendon repair at four weeks post treatment with sutures coated with varying concentrations of rhPDGF-BB, relative to buffer-coated suture repairs.
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Effect of rhPDGF-BB-Coated Sutures on Tendon Healing in a Rat Model: A Histological and Biomechanical Study
S. Cummings,
S. Cummings
North Shore Long Island Jewish Health System, Manhasset, NY
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J. Dines,
J. Dines
Hospital for Special Surgery, New York, NY
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C. K. Hee,
C. K. Hee
BioMimetic Therapeutics, Inc., Franklin, TN
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H. K. Kestler,
H. K. Kestler
BioMimetic Therapeutics, Inc., Franklin, TN
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C. M. Roden,
C. M. Roden
BioMimetic Therapeutics, Inc., Franklin, TN
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N. Shah,
N. Shah
Feinstein Institute for Medical Research, Manhasset, NY
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P. Razzano,
P. Razzano
Feinstein Institute for Medical Research, Manhasset, NY
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D. Dines,
D. Dines
Hospital for Special Surgery, New York, NY
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N. Chahine,
N. Chahine
Feinstein Institute for Medical Research, Manhasset, NY
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D. Grande
D. Grande
North Shore Long Island Jewish Health System, Manhasset, NY
Feinstein Institute for Medical Research, Manhasset, NY
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S. Cummings
North Shore Long Island Jewish Health System, Manhasset, NY
J. Dines
Hospital for Special Surgery, New York, NY
C. K. Hee
BioMimetic Therapeutics, Inc., Franklin, TN
H. K. Kestler
BioMimetic Therapeutics, Inc., Franklin, TN
C. M. Roden
BioMimetic Therapeutics, Inc., Franklin, TN
N. Shah
Feinstein Institute for Medical Research, Manhasset, NY
P. Razzano
Feinstein Institute for Medical Research, Manhasset, NY
D. Dines
Hospital for Special Surgery, New York, NY
N. Chahine
Feinstein Institute for Medical Research, Manhasset, NY
D. Grande
North Shore Long Island Jewish Health System, Manhasset, NY
Feinstein Institute for Medical Research, Manhasset, NY
Paper No:
SBC2011-53629, pp. 585-586; 2 pages
Published Online:
July 17, 2013
Citation
Cummings, S, Dines, J, Hee, CK, Kestler, HK, Roden, CM, Shah, N, Razzano, P, Dines, D, Chahine, N, & Grande, D. "Effect of rhPDGF-BB-Coated Sutures on Tendon Healing in a Rat Model: A Histological and Biomechanical Study." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 585-586. ASME. https://doi.org/10.1115/SBC2011-53629
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