Essential to growing or regenerating 3-dimensional tissues is the formation of functional microcirculation that provides nutrients, oxygen and signal molecules for tissue survival and function regeneration. In the past decade, molecule-based microvascular formation has been achieved in vitro and in vivo. However, direct delivery of angiogenic molecules often results in malformed hyperpermeable microvessels, microvessels with low density. This can be attributed to the lack of effective molecule mechanisms that regulate vascular formation. More recent studies utilize biodegradable materials to control the delivery of biomolecules for vascularization of engineered or ischemic tissues, and exciting results have shown the importance of molecule kinetics to the vascular formation. Molecule delivery mechanisms that mimic precisely-regulated spatiotemporal signaling events during natural vascularization may be a possible way to improve or optimize the process. Hence, this study is designed to develop a new release system capable of degrading in the body and releasing biomolecules in a spatiotemporally controlled manner.
Skip Nav Destination
ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Nanofiber Micropatterns for Controlled Release of Biomolecules
Walter Bonani,
Walter Bonani
University of Colorado at Boulder, Boulder, CO
Search for other works by this author on:
Claudio Migliaresi,
Claudio Migliaresi
University of Colorado at Boulder, Boulder, CO
University of Trento, Trento, Italy
Search for other works by this author on:
Wei Tan
Wei Tan
University of Colorado at Denver, Aurora, CO
Search for other works by this author on:
Walter Bonani
University of Colorado at Boulder, Boulder, CO
Claudio Migliaresi
University of Colorado at Boulder, Boulder, CO
University of Trento, Trento, Italy
Wei Tan
University of Colorado at Denver, Aurora, CO
Paper No:
SBC2011-53816, pp. 575-576; 2 pages
Published Online:
July 17, 2013
Citation
Bonani, W, Migliaresi, C, & Tan, W. "Nanofiber Micropatterns for Controlled Release of Biomolecules." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 575-576. ASME. https://doi.org/10.1115/SBC2011-53816
Download citation file:
2
Views
Related Proceedings Papers
Oxygen-Sensing Microfluidic Scaffolds
ICNMM2009
Related Articles
Nanofiber Covered Stent (NCS) for Vascular Diseases
J. Med. Devices (June,2008)
Intra-Operative Pulse Oximetry
J. Med. Devices (June,2009)
Diagnostics of Human Body Cavities Using Diode Laser Gas Spectroscopy
J. Med. Devices (June,2008)
Related Chapters
Conclusion & executive summary
Photodynamic Therapy Mediated by Fullerenes and their Derivatives
Characterization and evaluation
Biocompatible Nanomaterials for Targeted and Controlled Delivery of Biomacromolecules
Mining Association Rules for Trajectories of Spatiotemporal Data
International Conference on Instrumentation, Measurement, Circuits and Systems (ICIMCS 2011)