The acute respiratory distress syndrome (ARDS) is a devastating lung disease in which bacterial infections cause disruption of the blood-gas barrier, flooding and occlusion of pulmonary airways. Patients with ARDS must be placed on a mechanical ventilator to survive. Unfortunately, these ventilators also exacerbate the existing lung injury and as a result the mortality for ARDS is high (∼30–40%). Experimental studies [1,2,3] indicate that the hydrodynamic forces generated during microbubble flows can cause cell death, further barrier disruption and the up-regulation of inflammatory cascades.
- Bioengineering Division
Computational Model of Microbubble Flows During the Reopening of Airways
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Chen, X, & Ghadiali, S. "Computational Model of Microbubble Flows During the Reopening of Airways." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 543-544. ASME. https://doi.org/10.1115/SBC2011-53717
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