The pathogenesis of abdominal aortic aneurysm (AAA) formation still remains debated. Hemodynamics have been suggested to play a (modulating) role, but no follow-up studies have been performed due to (a.o.) a lack of human data before disease initiation. We therefore used an established mouse model of AAA  to study whether AAA develops at locations experiencing disturbed flow. We set up a framework to obtain mouse-specific Computational Fluid Dynamics (CFD) simulations of the mouse abdominal aorta, combining: (i) an in vivo assessed geometric model  and (ii) in vivo measured boundary conditions. A distance map was generated to link baseline and end-stage aortic morphologies after AAA development, and the relationship between baseline hemodynamics and end-stage dilatation was quantified.
- Bioengineering Division
A Quantitative Comparison Between Baseline Hemodynamics and End-Stage Aneurysm Formation in ApoE −/− Mice
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Trachet, B, Renard, M, De Santis, G, Staelens, S, De Backer, J, Antiga, L, Loeys, B, & Segers, P. "A Quantitative Comparison Between Baseline Hemodynamics and End-Stage Aneurysm Formation in ApoE −/− Mice." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 453-454. ASME. https://doi.org/10.1115/SBC2011-53452
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