Despite this innate regenerative potential of the peripheral nervous system, functional recovery often remains incomplete, especially as the severity of injury increases. This has been attributed to a number of sources including the ingrowth of fibrous scar tissue, lack of mechanical support for emerging neurites, and the malrouted reinnervation of neurites towards inappropriate targets. While research in the field is broad, it is generally accepted that an optimal nerve guidance conduit to encourage regeneration should include both biological and mechanical support for emerging neurites and glia.

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