Cancer is a leading cause of death in the US, and tumor cell metastasis and secondary tumor formation are key factors in the malignancy and prognosis of the disease. The regulation of cell motility plays an important role in the migration and invasion of cancer cells into surrounding tissues. The primary modes of increased motility in cancerous tissues may include collective migration of a group of epithelial cells during tumor growth and single cell migration of mesenchymal cells after detachment from the primary tumor site [1]. In epithelial cancers, metastasizing cells lose their cell-cell adhesions, detach from the tumor mass, begin expressing mesenchymal markers, and become highly motile and invasive, a process known as epithelial-to-mesenchymal transition (EMT) (Fig. 1) [2]. Although the cellular and biochemical signaling mechanisms underlying EMT have been studied extensively, there is limited information about the biomechanical mechanisms of EMT. In particular, it is not known how changes in cell mechanics (cell stiffness, cell-cell adhesion strength, traction forces) influence the detachment, migration and invasion processes that occur during metastasis.
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Multi-Scale Modeling of Cancer Cell Migration and Adhesion During Epithelial-to-Mesenchymal Transition
Rachel Zielinski,
Rachel Zielinski
The Ohio State University, Columbus, OH
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Cosmin Mihai,
Cosmin Mihai
The Ohio State University, Columbus, OH
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Samir Ghadiali
Samir Ghadiali
The Ohio State University, Columbus, OH
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Rachel Zielinski
The Ohio State University, Columbus, OH
Cosmin Mihai
The Ohio State University, Columbus, OH
Samir Ghadiali
The Ohio State University, Columbus, OH
Paper No:
SBC2011-53511, pp. 405-406; 2 pages
Published Online:
July 17, 2013
Citation
Zielinski, R, Mihai, C, & Ghadiali, S. "Multi-Scale Modeling of Cancer Cell Migration and Adhesion During Epithelial-to-Mesenchymal Transition." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 405-406. ASME. https://doi.org/10.1115/SBC2011-53511
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