Extracellular matrix (ECM) bioscaffolds derived from animal sources, such as porcine small intestine submucosa (SIS) and urinary bladder matrix (UBM), have a successful history for application in clinical and/or experimental settings [1]. In our research center, we have demonstrated that the porcine SIS bioscaffolds could improve the morphological, biochemical, and biomechanical properties of healing ligaments and tendons in different animal models [2, 3].

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