Diabetic patients are unable to effectively regulate blood glucose, which leads to periods of both hypo- and hyperglycemia [1]. High glucose increases reactive oxygen species formation [2], permeability [3], apoptosis [4], and basement membrane protein production [5] in endothelial cells. Recently hypoglycemia has been proposed to increase reactive species and apoptosis [6] and upregulate VEGF [7].
Volume Subject Area:
Mechanotransduction and Sub-Cellular Biophysics III
Topics:
Endothelial cells,
Fibers,
Fluids,
Shear stress,
Blood glucose,
Diabetes,
Glucose,
Membranes,
Oxygen,
Permeability,
Proteins
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