A fibrotic scar in the myocardium is characterized by excessive extracellular matrix deposition, loss of functioning cardiomyocytes, and the transition of healthy cardiac fibroblasts to a myofibroblast phenotype. Previous research has suggested that the myofibroblast transition is mediated by mechanical stimuli including cyclic strain [1–2] and interstitial fluid flow [3–5].
Volume Subject Area:
Mechanotransduction and Sub-Cellular Biophysics II
This content is only available via PDF.
Copyright © 2011 by ASME
You do not currently have access to this content.