A fibrotic scar in the myocardium is characterized by excessive extracellular matrix deposition, loss of functioning cardiomyocytes, and the transition of healthy cardiac fibroblasts to a myofibroblast phenotype. Previous research has suggested that the myofibroblast transition is mediated by mechanical stimuli including cyclic strain [1–2] and interstitial fluid flow [3–5].
- Bioengineering Division
Cyclic Strain and Interstitial Flow Modulate Cardiac Fibroblast Phenotype Through Angiotensin II and TGF-β Pathways
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Galie, PA, & Stegemann, JP. "Cyclic Strain and Interstitial Flow Modulate Cardiac Fibroblast Phenotype Through Angiotensin II and TGF-β Pathways." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 341-342. ASME. https://doi.org/10.1115/SBC2011-53924
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