Bone loss is a critical health problem of astronauts in long-term space missions. A growing number of evidence has pointed out bone fluid flow as a critical regulator in mechanotransductive signaling and bone adaptation. Intramedullary pressure (ImP) is a key mediator for bone fluid flow initiation and it influences the osteogenic signals within the skeleton. The potential ImP-induced bone fluid flow then triggers bone adaptation [1]. Previous in vivo study has demonstrated that ImP induced by oscillatory electrical stimulations can effectively mitigate disuse osteopenia in a frequency-dependent manner in a disuse rat model [2, 3]. In order to develop the translational potentials of ImP, a non-invasive intervention with direct fluid flow coupling is necessary to develop new treatments for microgravity-induced osteopenia/osteoporosis.
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Induced Intramedullary Pressure by Dynamic Hydraulic Stimulation and Its Potential in Attenuation of Bone Loss
J. Cheng,
J. Cheng
Stony Brook University, Stony Brook, NY
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S. Ferreri,
S. Ferreri
Stony Brook University, Stony Brook, NY
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F. Serra-Hsu,
F. Serra-Hsu
Stony Brook University, Stony Brook, NY
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Y. X. Qin
Y. X. Qin
Stony Brook University, Stony Brook, NY
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M. Hu
Stony Brook University, Stony Brook, NY
J. Cheng
Stony Brook University, Stony Brook, NY
S. Ferreri
Stony Brook University, Stony Brook, NY
F. Serra-Hsu
Stony Brook University, Stony Brook, NY
W. Lin
Stony Brook University, Stony Brook, NY
Y. X. Qin
Stony Brook University, Stony Brook, NY
Paper No:
SBC2011-54015, pp. 317-318; 2 pages
Published Online:
July 17, 2013
Citation
Hu, M, Cheng, J, Ferreri, S, Serra-Hsu, F, Lin, W, & Qin, YX. "Induced Intramedullary Pressure by Dynamic Hydraulic Stimulation and Its Potential in Attenuation of Bone Loss." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 317-318. ASME. https://doi.org/10.1115/SBC2011-54015
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