The ability of tissues to adapt to the mechanical environment is a remarkable feature of the skeleton. Although the mechano-regulation process is very complex, several mechano-regulation theories for musculo-skeletal tissues have successfully predicted the tissue differentiation and remodelling process in various scenarios with reasonable accuracy (1,2); but how did mechano-regulated bone differentiation emerge in evolution? Early vertebrates, like cartilaginous fishes, could modulate their tissues to the mechanical environment and it is likely that evolution worked with the regulatory genes for skeletal tissues, rather than changes in structural genes, i.e. adapting skeletal tissues to the local conditions rather than involving major changes in cells or tissue types (3).
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Simulation of the Emergence of the Endochondral Ossification Process in Evolution Available to Purchase
Hanifeh Khayyeri,
Hanifeh Khayyeri
Trinity College Dublin, Dublin, Ireland
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Patrick J. Prendergast
Patrick J. Prendergast
Trinity College Dublin, Dublin, Ireland
Search for other works by this author on:
Hanifeh Khayyeri
Trinity College Dublin, Dublin, Ireland
Patrick J. Prendergast
Trinity College Dublin, Dublin, Ireland
Paper No:
SBC2011-53714, pp. 311-312; 2 pages
Published Online:
July 17, 2013
Citation
Khayyeri, H, & Prendergast, PJ. "Simulation of the Emergence of the Endochondral Ossification Process in Evolution." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 311-312. ASME. https://doi.org/10.1115/SBC2011-53714
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