Despite major advances in treatment of coronary heart disease, apparently healthy patients die suddenly. Rupture of vulnerable fibroatheroma plaques in coronary arteries cause more than 250,000 deaths a year, yet the mechanisms as to why some caps rupture and some others do not, remain unknown. The current criterion to consider a fibroatheroma as “vulnerable” or prone to rupture is the thickness of its fibrous cap. However, available screening techniques and the cap thickness criterion have been shown to be insufficient to identify the victims before the event occurs.

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