Longitudinal Image Based Study of Cerebral Aneurysms: Growth, Contacts and Hemodynamics During Aneurysmal Progression

Improving current procedures for the evaluation and treatment of cerebral aneurysms requires a better understanding of the underlying mechanisms governing their formation, progression and rupture. It is generally accepted that these mechanisms are multi-factorial, involving: hemodynamics, wall biomechanics and mechano-biology, and contacts with peri-aneurysmal structures [1]. However, little is known about the relative importance and interactions of these factors. The broad objective of our research is to investigate the mechanisms of aneurysm progression by studying cerebral aneurysms that are followed longitudinally in time with non-invasive 3D imaging. In this context, the goal of this paper is to highlight the importance of considering possible contacts between the aneurysm and peri-aneurysmal structures and studying their effects on the aneurysm evolution. For this purpose, we present a computational analysis of a growing aneurysm in contact with bones at the base of the skull.