Although mitral valve (MV) repair surgeries are commonly performed, their long-term durability has not been completely satisfying. In most cases, failure was a result of disruption at the leaflet, chordae, or annular suture lines. These failure modes suggest excessive stress and the resulting tissue damage as etiologic factors. The purpose of this study was to develop a method to better estimate functional dynamic in-vivo stresses in the MV anterior leaflet (AL) midsection. The stress was computed from the dynamic in-vivo strain measured experimentally. Numerous in-vivo and in-vitro studies (e.g. [3, 4]) have been conducted to quantify MV dynamic strain. We used in-vivo strain data obtained from our well-established ovine model [4]. To calculate the in-vivo strain, we employed the actual unloaded state of the tissue as the reference frame, measured for the first time in this study. The AL stress was then computed using our nonlinear structural constitutive model [5].
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Functional Dynamic In-Vivo Stresses of the Mitral Valve Anterior Leaflet
Rouzbeh Amini,
Rouzbeh Amini
University of Pittsburgh, Pittsburgh, PA
University of Pittsburgh Medical Center, Pittsburgh, PA
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Chad E. Eckert,
Chad E. Eckert
University of Pittsburgh, Pittsburgh, PA
University of Pittsburgh Medical Center, Pittsburgh, PA
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Christopher A. Carruthers,
Christopher A. Carruthers
University of Pittsburgh, Pittsburgh, PA
University of Pittsburgh Medical Center, Pittsburgh, PA
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Kevin Koomalsingh,
Kevin Koomalsingh
University of Pennsylvania, Philadelphia, PA
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Mashito Minakawa,
Mashito Minakawa
University of Pennsylvania, Philadelphia, PA
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Robert C. Gorman,
Robert C. Gorman
University of Pennsylvania, Philadelphia, PA
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Joseph H. Gorman,
Joseph H. Gorman
University of Pennsylvania, Philadelphia, PA
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Michael S. Sacks
Michael S. Sacks
University of Pittsburgh, Pittsburgh, PA
University of Pittsburgh Medical Center, Pittsburgh, PA
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Rouzbeh Amini
University of Pittsburgh, Pittsburgh, PA
University of Pittsburgh Medical Center, Pittsburgh, PA
Chad E. Eckert
University of Pittsburgh, Pittsburgh, PA
University of Pittsburgh Medical Center, Pittsburgh, PA
Christopher A. Carruthers
University of Pittsburgh, Pittsburgh, PA
University of Pittsburgh Medical Center, Pittsburgh, PA
Kevin Koomalsingh
University of Pennsylvania, Philadelphia, PA
Mashito Minakawa
University of Pennsylvania, Philadelphia, PA
Robert C. Gorman
University of Pennsylvania, Philadelphia, PA
Joseph H. Gorman
University of Pennsylvania, Philadelphia, PA
Michael S. Sacks
University of Pittsburgh, Pittsburgh, PA
University of Pittsburgh Medical Center, Pittsburgh, PA
Paper No:
SBC2011-53925, pp. 257-258; 2 pages
Published Online:
July 17, 2013
Citation
Amini, R, Eckert, CE, Carruthers, CA, Koomalsingh, K, Minakawa, M, Gorman, RC, Gorman, JH, & Sacks, MS. "Functional Dynamic In-Vivo Stresses of the Mitral Valve Anterior Leaflet." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 257-258. ASME. https://doi.org/10.1115/SBC2011-53925
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