Calcific Aortic Valve Disease (CAVD) is the third most common cause of cardiovascular disease, affecting nearly 5 million people in the United States alone. It is now the most common form of acquired valvular disease in industrialized countries and will likely affect more individuals in the coming years as the prevalence increases with life expectancy. It is known that the progression of CAVD is closely related to the behavior of aortic valve interstitial cells (AVICs); however the cellular mechanobiological mechanisms leading to dysfunction remain unclear. Generally, CAVD is characterized by the formation of calcified AVIC aggregates with an apoptotic core. These aggregates increase the leaflet stiffness and impede normal valve function. Multiple studies have investigated the effects of various biochemical cues on this process, such as transformation growth factor β1 (TGF-β1), on the regulation of nodule formation [1]. Additionally, Yip et al revealed that matrix stiffness controls nodule formation in vitro, with stiffer substrates promoting apoptotic nodule formation, while compliant substrates generated nodules containing cells with osteoblast markers [2]. This suggests that matrix stiffness is involved in the regulatory mechanisms of nodule formation and may initiate different types of nodule formation (i.e. osteogenic vs. dystrophic). In the current study, we examined the synergistic role of strain and TGF-β1 in the generation of calcified nodules AVICs.
Skip Nav Destination
ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Calcific Nodule Morphogenesis by Aortic Valve Interstitial Cells: Synergism of Applied Strain and TGF-β1 Available to Purchase
Joseph Chen,
Joseph Chen
Vanderbilt University, Nashville, TN
Search for other works by this author on:
Charles I. Fisher,
Charles I. Fisher
Vanderbilt University, Nashville, TN
Search for other works by this author on:
M. K. Sewell-Loftin,
M. K. Sewell-Loftin
Vanderbilt University, Nashville, TN
Search for other works by this author on:
W. David Merryman
W. David Merryman
Vanderbilt University, Nashville, TN
Search for other works by this author on:
Joseph Chen
Vanderbilt University, Nashville, TN
Charles I. Fisher
Vanderbilt University, Nashville, TN
M. K. Sewell-Loftin
Vanderbilt University, Nashville, TN
W. David Merryman
Vanderbilt University, Nashville, TN
Paper No:
SBC2011-53899, pp. 243-244; 2 pages
Published Online:
July 17, 2013
Citation
Chen, J, Fisher, CI, Sewell-Loftin, MK, & Merryman, WD. "Calcific Nodule Morphogenesis by Aortic Valve Interstitial Cells: Synergism of Applied Strain and TGF-β1." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 243-244. ASME. https://doi.org/10.1115/SBC2011-53899
Download citation file:
5
Views
Related Proceedings Papers
Related Articles
3D CAD Based Conceptual Design of a Novel Aortic Valve Stent
J. Med. Devices (June,2009)
Nanofiber Covered Stent (NCS) for Vascular Diseases
J. Med. Devices (June,2008)
Evolution of a Non-Invasive Method for Providing Assistance to the Heart
J. Med. Devices (June,2009)
Related Chapters
Introduction
Modified Detrended Fluctuation Analysis (mDFA)
Occlusion Identification and Relief within Branched Structures
Biomedical Applications of Vibration and Acoustics in Therapy, Bioeffect and Modeling
Effects of Mechanical Vibration on Cultured Osteoblasts in Relation to Fracture Healing
Biomedical Applications of Vibration and Acoustics in Therapy, Bioeffect and Modeling