Although risk factors for atherosclerosis such as genetic predisposition and diet are systemic, the disease develops non-uniformly throughout the arterial system. Lesions preferentially occur in curved arteries and branching regions and their distribution has been observed to change with age in both humans and rabbits [1]. If local blood flow patterns play a role in the initiation of atherosclerosis, the age-related differences may be a consequence of changes in the flow characteristics.
Volume Subject Area:
Atherosclerosis I
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