Recently, minimally-invasive transcatheter aortic valve (TAV) replacement has emerged as a viable alternative to traditional open-chest heart valve replacement for high risk patients who otherwise have limited or no treatment options. Although significant experience with TAV procedures has been gained, various adverse effects have been observed after device implantation [1, 2]. One adverse event is the impairment of coronary artery flow. Because the TAV stent pushes the native leaflets towards the sinus of Valsalva during TAV deployment, the flow boundaries in the aortic root are consequently altered. A worst case scenario would be the occlusion of the coronary ostia. Reduced flow to the coronary arteries has also been observed for some patients following TAV intervention [3]. With IRB approval, we recently conducted a dimensional analysis of 3D aortic root geometries, reconstructed from 64-slice CT scans of 95 patients [4]. TAV-relevant dimensions were measured. The spatial distribution of the left coronary ostium was quantified (Fig. 1). In this study, we will construct a patient-specific aortic root model with varied coronary ostium locations as shown in Fig. 1, and perform a combined finite element analysis (FEA) and computational fluid dynamics (CFD) simulation to investigate hemodynamic environment changes that occur following TAV intervention.
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Fluid Study of Transcatheter Aortic Valve Deployment Into Patients With Varying Coronary Ostia Position Available to Purchase
Eric Sirois,
Eric Sirois
University of Connecticut, Storrs, CT
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Qian Wang,
Qian Wang
University of Connecticut, Storrs, CT
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Susheel Kodali,
Susheel Kodali
Columbia University College of Physicians and Surgeons, New York, NY
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Wei Sun
Wei Sun
University of Connecticut, Storrs, CT
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Eric Sirois
University of Connecticut, Storrs, CT
Qian Wang
University of Connecticut, Storrs, CT
Susheel Kodali
Columbia University College of Physicians and Surgeons, New York, NY
Wei Sun
University of Connecticut, Storrs, CT
Paper No:
SBC2011-53891, pp. 177-178; 2 pages
Published Online:
July 17, 2013
Citation
Sirois, E, Wang, Q, Kodali, S, & Sun, W. "Fluid Study of Transcatheter Aortic Valve Deployment Into Patients With Varying Coronary Ostia Position." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 177-178. ASME. https://doi.org/10.1115/SBC2011-53891
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