In the United States, over one million patients sustain left ventricular (LV) injury after myocardial infarction (MI). LV remodeling is an adaptive process of hypertrophy that includes infarct expansion, reduced contractility and LV dilation. Progressive enlargement of non-ischemic, hypocontractile myocardium in the adjacent zone (AZ) following the transmural MI has been identified clinically, which contributes to the development post-MI cardiomyopathy in patients. Till now, how the early regional biomechanical and cellular changes, particularly in the AZ, relate to LV remodeling process remains incompletely understood. This study aims to investigate the temporal and/or spatial variations of strain/stress and myocyte size in an ovine model with various MI sizes.
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Analysis of Infarct Size on Myocardial Infarction Remodeling
Pei Zhang,
Pei Zhang
University of Maryland School of Medicine, Baltimore, MD
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Tieluo Li,
Tieluo Li
University of Maryland School of Medicine, Baltimore, MD
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Katrina Williams,
Katrina Williams
University of Maryland School of Medicine, Baltimore, MD
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Shuyin Li,
Shuyin Li
University of Maryland School of Medicine, Baltimore, MD
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Xufeng Wei,
Xufeng Wei
University of Maryland School of Medicine, Baltimore, MD
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Hosung Son,
Hosung Son
University of Maryland School of Medicine, Baltimore, MD
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Pablo Sanchez,
Pablo Sanchez
University of Maryland School of Medicine, Baltimore, MD
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Bartley P. Griffith,
Bartley P. Griffith
University of Maryland School of Medicine, Baltimore, MD
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Zhongjun J. Wu
Zhongjun J. Wu
University of Maryland School of Medicine, Baltimore, MD
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Pei Zhang
University of Maryland School of Medicine, Baltimore, MD
Tieluo Li
University of Maryland School of Medicine, Baltimore, MD
Katrina Williams
University of Maryland School of Medicine, Baltimore, MD
Shuyin Li
University of Maryland School of Medicine, Baltimore, MD
Xufeng Wei
University of Maryland School of Medicine, Baltimore, MD
Hosung Son
University of Maryland School of Medicine, Baltimore, MD
Pablo Sanchez
University of Maryland School of Medicine, Baltimore, MD
Bartley P. Griffith
University of Maryland School of Medicine, Baltimore, MD
Zhongjun J. Wu
University of Maryland School of Medicine, Baltimore, MD
Paper No:
SBC2011-53117, pp. 147-148; 2 pages
Published Online:
July 17, 2013
Citation
Zhang, P, Li, T, Williams, K, Li, S, Wei, X, Son, H, Sanchez, P, Griffith, BP, & Wu, ZJ. "Analysis of Infarct Size on Myocardial Infarction Remodeling." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 147-148. ASME. https://doi.org/10.1115/SBC2011-53117
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