The loss of functional muscle from genetic disease, traumatic injury, or surgical excisions results in a physiologic deficiency that continues to remain without an effective clinical treatment . Engineering functional muscle tissue in vitro for replacement in vivo may offer a potential remedy for this clinical demand. However, in vitro muscle constructs in two- and three-dimensions have yet to fully exhibit the dynamic mechanical responses of physiological muscle . Furthermore, the application of mechanical and electrical stimulation in vitro has shown promise for growing contractile tissue , but these have been limited to 2-D and/or rely on inhibitory scaffold techniques. For these reasons, we sought a new approach to utilize both extrinsic growth and maturation cues, in addition to the myoblasts’ innate propensity to differentiate and produce functional myotubes in vitro, for the development of clinically-relevant skeletal muscle replacements.
- Bioengineering Division
An Electromechanical Bioreactor for Scaffold-Free Skeletal Muscle Tissue Engineering
- Views Icon Views
- Share Icon Share
- Search Site
Koppes, RA, Schiele, NR, & Corr, DT. "An Electromechanical Bioreactor for Scaffold-Free Skeletal Muscle Tissue Engineering." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 135-136. ASME. https://doi.org/10.1115/SBC2011-53415
Download citation file: