The loss of functional muscle from genetic disease, traumatic injury, or surgical excisions results in a physiologic deficiency that continues to remain without an effective clinical treatment [1]. Engineering functional muscle tissue in vitro for replacement in vivo may offer a potential remedy for this clinical demand. However, in vitro muscle constructs in two- and three-dimensions have yet to fully exhibit the dynamic mechanical responses of physiological muscle [2]. Furthermore, the application of mechanical and electrical stimulation in vitro has shown promise for growing contractile tissue [3], but these have been limited to 2-D and/or rely on inhibitory scaffold techniques. For these reasons, we sought a new approach to utilize both extrinsic growth and maturation cues, in addition to the myoblasts’ innate propensity to differentiate and produce functional myotubes in vitro, for the development of clinically-relevant skeletal muscle replacements.
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
An Electromechanical Bioreactor for Scaffold-Free Skeletal Muscle Tissue Engineering Available to Purchase
Ryan A. Koppes,
Ryan A. Koppes
Rensselaer Polytechnic Institute, Troy, NY
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Nathan R. Schiele,
Nathan R. Schiele
Rensselaer Polytechnic Institute, Troy, NY
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David T. Corr
David T. Corr
Rensselaer Polytechnic Institute, Troy, NY
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Ryan A. Koppes
Rensselaer Polytechnic Institute, Troy, NY
Nathan R. Schiele
Rensselaer Polytechnic Institute, Troy, NY
David T. Corr
Rensselaer Polytechnic Institute, Troy, NY
Paper No:
SBC2011-53415, pp. 135-136; 2 pages
Published Online:
July 17, 2013
Citation
Koppes, RA, Schiele, NR, & Corr, DT. "An Electromechanical Bioreactor for Scaffold-Free Skeletal Muscle Tissue Engineering." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 135-136. ASME. https://doi.org/10.1115/SBC2011-53415
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