Skeletal muscle has a complex hierarchical structure which is mainly composed of myofibers and the surrounding extracellular matrix (ECM) including endomysium, perimysium, and epimysium. Myofibers are long, cylindrical, multinucleated cells composed of repeating sarcomeres, which are basic functional units for skeletal muscle contraction. In order to produce body movement, the force generated by myofiber has to be transmitted from individual fiber to the tendon. The commonly accepted site for force transmission is the myotendinous junction (MTJ) where the myofibers connect to the tendon. However, the myofibers mainly end within the muscle fascicles without reaching the MTJ in many muscles, in which case the force has to be transmitted laterally to adjacent fiber through shear and to the tendon eventually.

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