Stiff vertebral bone and compliant hyaline articular cartilage (HAC) anchor together through a thin (∼100’s of microns) region of articular calcified cartilage (ACC). This bone–cartilage, or osteochondral (OC), interface may play a role in osteoarthritis pathogenesis through increased mineralization, disrupting loading, and damaging neighboring tissues [1,2]. Load transmission through OC regions is poorly understood, thus limiting understanding of disease progression and ability to engineer OC interface-like tissues .
- Bioengineering Division
Distribution of Nanomechanical Properties and Mineralization of the Osteochondral Interface in the Femoral Head
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Pak, R, Campbell, SE, Paietta, RC, & Ferguson, VL. "Distribution of Nanomechanical Properties and Mineralization of the Osteochondral Interface in the Femoral Head." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 1277-1278. ASME. https://doi.org/10.1115/SBC2011-53345
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