Modeling of Isoelectric Focusing of Type-I Collagen Molecules Under Uniform Electric Field

Our laboratory developed an electrochemical method which transforms collagen solutions to solid state material by densification and unidirectional alignment of molecules [1] based on the principles of isoelectric focusing (IEF). Randomly oriented molecules at the onset migrate to the isoelectic plane when current is applied to the solution. However, the driving forces behind the focusing phenomena are not fully understood.