Congenital abnormalities of the main pulmonary artery (MPA) and ascending aorta (AA) often necessitate surgical repair or the use of a valved conduit replacement, requiring multiple re-interventions due to regurgitation or failure of the prosthetic conduit. In recent years there has been a growing interest in the development of a living autologous tissue graft that could address the critical need for growing substitutes in the repair of congenital cardiovascular defects [1]. Regardless of the particulars of the therapeutic approach, the detailed growth characteristics of the native artery is required to establish the baseline dimensional changes post-implantation. During normal embryogenesis the Truncus Arteriosus begins to split and form into the anterior pulmonary artery and the posterior aorta [2]. Due to their common embryologic origin from a single outflow tract, there are disease conditions that originate in one artery and eventually affect both arteries [3]. Therefore, the postnatal growth deformation of both the MPA and AA was computed to quantify the effects of the mechanical association of these two arteries.
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Effect of In Vivo Physical Interaction of the Ascending Aorta and Main Pulmonary Artery on Postnatal Surface Growth Patterns in Ovine
Bahar Fata,
Bahar Fata
University of Pittsburgh, Pittsburgh, PA
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Danielle Gottlieb,
Danielle Gottlieb
Children’s Hospital of Boston/Harvard Medical School, Boston, MA
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John E. Mayer,
John E. Mayer
Children’s Hospital of Boston/Harvard Medical School, Boston, MA
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Michael S. Sacks
Michael S. Sacks
University of Pittsburgh, Pittsburgh, PA
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Bahar Fata
University of Pittsburgh, Pittsburgh, PA
Danielle Gottlieb
Children’s Hospital of Boston/Harvard Medical School, Boston, MA
John E. Mayer
Children’s Hospital of Boston/Harvard Medical School, Boston, MA
Michael S. Sacks
University of Pittsburgh, Pittsburgh, PA
Paper No:
SBC2011-53978, pp. 1203-1204; 2 pages
Published Online:
July 17, 2013
Citation
Fata, B, Gottlieb, D, Mayer, JE, & Sacks, MS. "Effect of In Vivo Physical Interaction of the Ascending Aorta and Main Pulmonary Artery on Postnatal Surface Growth Patterns in Ovine." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 1203-1204. ASME. https://doi.org/10.1115/SBC2011-53978
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