Mechanical loading protocols in tissue engineering (TE) aim to improve the deposition of a properly organized collagen fiber network. These conditioning protocols can result in tissue compaction , which may lead to loss of functionality of the tissue construct. A balance between the collagen deposition and compaction is desirable, yet difficult to achieve, due to the nonlinear coupling between mechanical loading, collagen modeling and compaction.
- Bioengineering Division
The Role of Cells in Collagen Modeling in Tissue Engineered Constructs: A Theoretical Framework
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Soares, ALF, van Vlimmeren, MAA, Oomens, CWJ, & Baaijens, FPT. "The Role of Cells in Collagen Modeling in Tissue Engineered Constructs: A Theoretical Framework." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 1189-1190. ASME. https://doi.org/10.1115/SBC2011-53263
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