Endothelial cells (ECs) undergoing cyclic stretch align perpendicularly to the stretch direction [1]. Phosphorylation of focal adhesion kinase (FAK), an important component of focal adhesion (FA) signaling pathways, is thought to be required for the stretch-dependent morphological response of ECs [1]. However, since it has been reported that FAK is not always required for EC response to cyclic stretch is regulated by multiple signal transduction pathways in ECs.

This content is only available via PDF.
You do not currently have access to this content.