Endothelial cells (ECs) undergoing cyclic stretch align perpendicularly to the stretch direction . Phosphorylation of focal adhesion kinase (FAK), an important component of focal adhesion (FA) signaling pathways, is thought to be required for the stretch-dependent morphological response of ECs . However, since it has been reported that FAK is not always required for EC response to cyclic stretch is regulated by multiple signal transduction pathways in ECs.
Volume Subject Area:Poster Session II: Cellular and Molecular Biomechanics
Topics:Endothelial cells, Junctions, Adhesion, Signals
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