In heart valve tissue engineering, appropriate mechanical preconditioning may provide the necessary stimuli to promote proper tissue formation [1–3]. Previous efforts have focused on a mechanistic heart valve (MHV) bioreactor that can mimic the innate mechanical stress states of flexure, flow and stretch in any combination thereof [1]. A fundamental component pertaining to heart valves is its dynamic behavior. Specific fluid-induced shears stress patterns may play a critical role in up-regulating ECM secretion by progenitor cell sources such as bone marrow derived stem cells [2] and increasing the possibility of cell differentiation towards a heart valve phenotype. Here, we take a computational predictive modeling approach to identify the specific fluid induced shear stress distributions that are altered as a result of valve-like movement and its resulting implications for tissue growth. Previous results have demonstrated the analogous deformation characteristics of heart valves in a rectangular geometry [2]. We conducted computational fluid dynamic (CFD) simulations of a bioreactor that houses these rectangular-shaped specimens (Fig.1).

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