For the past few years various photothermal methods such as Laser-induced Hyperthermia [1] and Laser Interstitial Thermal Therapy [2] has been developed for tumor ablation. In all of these existing techniques, either continuous wave (CW) or long pulse laser sources have been used, which often produces heat affected zones that are larger than the boundaries of the tumor, which leads to collateral damage of surrounding healthy tissue. Moreover for these applications, either collimated or diffused laser beams are used, resulting in much of the energy being absorbed by tissues at the skin surface and very little remaining energy penetrating the skin. Such drawbacks can be eliminated if a beam from a short pulse laser source is focused directly at the targeted subsurface location. Tight focusing ensures that sufficient intensity to drive nonlinear optical absorption can be achieved with low pulse energy. This technique has been effectively used in applications such as non-ablative dermal remodeling [3] and treatment of striated muscles [4]. However, the use of focused beam from an ultra-short pulse laser source has never been applied to tumor ablation and is investigated in this paper.
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ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Experimental and Numerical Analysis of Thermal Ablation in Biological Tissues Using Short Pulse Lasers
Amir Sajjadi,
Amir Sajjadi
Florida Institute of Technology, Melbourne, FL
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Ogugua Onyejekwe,
Ogugua Onyejekwe
Florida Institute of Technology, Melbourne, FL
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Kunal Mitra,
Kunal Mitra
Florida Institute of Technology, Melbourne, FL
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Michael S. Grace
Michael S. Grace
Florida Institute of Technology, Melbourne, FL
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Amir Sajjadi
Florida Institute of Technology, Melbourne, FL
Ogugua Onyejekwe
Florida Institute of Technology, Melbourne, FL
Kunal Mitra
Florida Institute of Technology, Melbourne, FL
Michael S. Grace
Florida Institute of Technology, Melbourne, FL
Paper No:
SBC2010-19627, pp. 997-998; 2 pages
Published Online:
July 15, 2013
Citation
Sajjadi, A, Onyejekwe, O, Mitra, K, & Grace, MS. "Experimental and Numerical Analysis of Thermal Ablation in Biological Tissues Using Short Pulse Lasers." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 997-998. ASME. https://doi.org/10.1115/SBC2010-19627
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