The process of angiogenesis is regulated by both chemical and mechanical signaling. While the role of chemical factors such as vascular endothelial growth factor (VEGF) during angiogenesis has been extensively studied, the influence of the mechanostructural environment on new vessel generation has received significantly less attention. During angiogenesis, endothelial cells in the existing vasculature detach and migrate out into the surrounding extracellular matrix (ECM), forming tubular structures that eventually mature into new blood vessels. This process is modulated by the structure and composition of the ECM [1]. The ECM is then remodeled by endothelial cells in the elongating neovessel tip, resulting in matrix condensation and changes in fiber orientation [2]. The mechanism as to how angiogenic vasculature and the ECM influence each other is poorly understood.
Skip Nav Destination
ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Three-Dimensional Simulation of In Vitro Angiogenesis: Effects of Extracellular Matrix Structure and Density Available to Purchase
Lowell Taylor Edgar,
Lowell Taylor Edgar
University of Utah, Salt Lake City, UT
Search for other works by this author on:
James E. Guilkey,
James E. Guilkey
University of Utah, Salt Lake City, UT
Search for other works by this author on:
Clayton J. Underwood,
Clayton J. Underwood
University of Utah, Salt Lake City, UT
Search for other works by this author on:
Brenda Baggett,
Brenda Baggett
University of Arizona, Tucson, AZ
Search for other works by this author on:
Urs Utzinger,
Urs Utzinger
University of Arizona, Tucson, AZ
Search for other works by this author on:
Jeffrey A. Weiss
Jeffrey A. Weiss
University of Utah, Salt Lake City, UT
Search for other works by this author on:
Lowell Taylor Edgar
University of Utah, Salt Lake City, UT
James E. Guilkey
University of Utah, Salt Lake City, UT
Clayton J. Underwood
University of Utah, Salt Lake City, UT
Brenda Baggett
University of Arizona, Tucson, AZ
Urs Utzinger
University of Arizona, Tucson, AZ
Jeffrey A. Weiss
University of Utah, Salt Lake City, UT
Paper No:
SBC2010-19502, pp. 931-932; 2 pages
Published Online:
July 15, 2013
Citation
Edgar, LT, Guilkey, JE, Underwood, CJ, Baggett, B, Utzinger, U, & Weiss, JA. "Three-Dimensional Simulation of In Vitro Angiogenesis: Effects of Extracellular Matrix Structure and Density." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 931-932. ASME. https://doi.org/10.1115/SBC2010-19502
Download citation file:
9
Views
Related Proceedings Papers
Related Articles
Elementary Mechanics of the Endothelium of Blood Vessels
J Biomech Eng (February,1993)
Bubble Motion in a Blood Vessel: Shear Stress Induced Endothelial Cell Injury
J Biomech Eng (July,2009)
Deformations and End Effects in Isolated Blood Vessel Testing
J Biomech Eng (January,2011)
Related Chapters
Application of an Integrated Approach Based on Zoning Search to Sentiment Analysis
International Conference on Measurement and Control Engineering 2nd (ICMCE 2011)
Condensation in Cool Roofs—Code Challenges, Field Observations, and Hygrothermal Modeling
Roofing Research and Standards Development: 10th Volume
Evaluation of Moisture Accumulation in Composite Roof Decks in High Humidity Environments such as Natatoriums in Cold Climates Using Hygrothermal Modeling
Roofing Research and Standards Development: 10th Volume