Carbon nanotubes (CNTs) are attractive materials for early detection, treatment, and imaging of cancer malignancies; however, they are limited by their inability to be monitored in vitro and in vivo [1]. Unlabeled CNTs are difficult to distinguish using elemental analysis because they are composed entirely of carbon, which is also characteristic of cellular membranes. Although some single walled nanotubes (SWNT) have been found to exhibit fluorescent properties, not all particles in a single batch fluoresce [2]. Additionally, these emissions may be too weak to be detected using conventional imaging modalities [3]. Incorporating fluorescent markers, such as fluorescent proteins or quantum dots, allows the non-fluorescent particles to be visualized. Previously, fluorophores, such as green fluorescent protein (GFP) or red fluorescent protein (RFP), have been used to visualize and track cells or other particles in biological environments, but their low quantum yield and tendency to photobleach generate limitations for their use in such applications.
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ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Cellular Uptake of Carbon Nanotubes Conjugated to Semiconductor Quantum Dots for Breast Cancer Imaging and Treatment Applications Available to Purchase
Kristen A. Zimmermann,
Kristen A. Zimmermann
Virginia Polytechnic Institute and State University, Blacksburg, VA
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Jianfei Zhang,
Jianfei Zhang
Virginia Polytechnic Institute and State University, Blacksburg, VA
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Harry Dorn,
Harry Dorn
Virginia Polytechnic Institute and State University, Blacksburg, VA
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Christopher Rylander,
Christopher Rylander
Virginia Polytechnic Institute and State University, Blacksburg, VA
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Marissa Nichole Rylander
Marissa Nichole Rylander
Virginia Polytechnic Institute and State University, Blacksburg, VA
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Kristen A. Zimmermann
Virginia Polytechnic Institute and State University, Blacksburg, VA
Jianfei Zhang
Virginia Polytechnic Institute and State University, Blacksburg, VA
Harry Dorn
Virginia Polytechnic Institute and State University, Blacksburg, VA
Christopher Rylander
Virginia Polytechnic Institute and State University, Blacksburg, VA
Marissa Nichole Rylander
Virginia Polytechnic Institute and State University, Blacksburg, VA
Paper No:
SBC2010-19504, pp. 77-78; 2 pages
Published Online:
July 15, 2013
Citation
Zimmermann, KA, Zhang, J, Dorn, H, Rylander, C, & Rylander, MN. "Cellular Uptake of Carbon Nanotubes Conjugated to Semiconductor Quantum Dots for Breast Cancer Imaging and Treatment Applications." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 77-78. ASME. https://doi.org/10.1115/SBC2010-19504
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