Osteoporosis is a skeletal disease resulting in diminished bone mass and altered bone microstructure, which leads to more fragile bones that have higher risk of fractures[1]. Approximately 44 million people have been diagnosed for osteoporosis nationwide[2]. It also causes nearly 1.5 million fractures annually. In order to prevent from such bone loss and to enhance bone quality, effective clinical treatments, e.g. using non-pharmacological approach, are in great need.

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