Nanomedicine poses a new frontier in medical technology with the advantages of targeted delivery and patient specific design. In applications of nanoparticle targeted drug delivery, the delivery efficiency is controlled by the physical properties of the nanoparticle such as its size, shape, ligand density, as well as external environmental conditions such as flow rate and blood vessel diameter. Proper drug dosage choice relies on determination of the attachment and detachment rates of the nanoparticles at the active region and the understanding of the complex process of targeted drug delivery. A few particulate models have been proposed to study the adhesion individual spherical or non-spherical nanoparticles on receptor coated wall. Meanwhile, continuum convection-diffusion-reaction models have been widely used to calculate the drug concentration under various conditions, which usually assumes specific binding and de-binding constants. In reality, these binding and de-binding rates largely vary with physical properties of the particles and local flow conditions. However, there has not been any study that links the particulate level nanoparticle size and shape information to the system level bounded particle concentration. A hybrid particle binding dynamics and continuum convection-diffusion-reaction model is presented to study the effect of shear flow rate and particle size on binding efficiency. The simulated concentration of bounded nanoparticles agrees well with experimental results in flow chamber studies.
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ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
A Coupled Particle-Continuum Model of Nanoparticle Targeted Delivery Under Vascular Flow With Experimental Validation Available to Purchase
Yaling Liu,
Yaling Liu
University of Texas at Arlington, Arlington, TX
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Kytai Nguyen,
Kytai Nguyen
University of Texas at Arlington, Arlington, TX
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Manohara Mariyappa,
Manohara Mariyappa
University of Texas at Arlington, Arlington, TX
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Soujanya Kona,
Soujanya Kona
University of Texas at Arlington, Arlington, TX
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Jifu Tan
Jifu Tan
University of Texas at Arlington, Arlington, TX
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Yaling Liu
University of Texas at Arlington, Arlington, TX
Kytai Nguyen
University of Texas at Arlington, Arlington, TX
Manohara Mariyappa
University of Texas at Arlington, Arlington, TX
Soujanya Kona
University of Texas at Arlington, Arlington, TX
Jifu Tan
University of Texas at Arlington, Arlington, TX
Paper No:
SBC2010-19035, pp. 75-76; 2 pages
Published Online:
July 15, 2013
Citation
Liu, Y, Nguyen, K, Mariyappa, M, Kona, S, & Tan, J. "A Coupled Particle-Continuum Model of Nanoparticle Targeted Delivery Under Vascular Flow With Experimental Validation." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 75-76. ASME. https://doi.org/10.1115/SBC2010-19035
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