Vascular diseases such as aneurysm and aortic dissection account for almost 16,000 deaths in the United States annually. In both of these diseases vascular inflammation is a common pathogenic factor. Another common pathologic feature of vascular disease includes structural matrix remodeling. It is also increasingly believed that inflammation may play a key role in the formation and progression of atherosclerotic vascular disease. Angiotensin II (AngII), a potent vasopressor, is also a strong inducer of vascular inflammation and aortic remodeling in atherosclerosis-prone mice. Based on this knowledge studies have been conducted using subcutaneous AngII infusion in order to produce aortic remodeling and aneurysm formation, with acute thoracic and abdominal aortic dissections [1].
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ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
The Effects of Angiotensin II Infusion on the Mechanical Response and Microstructural Organization of Mouse Aorta
Darren Haskett,
Darren Haskett
University of Arizona, Tucson, AZ
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Marie Fouts,
Marie Fouts
University of Arizona, Tucson, AZ
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Urs Utzinger,
Urs Utzinger
University of Arizona, Tucson, AZ
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Doug Larson,
Doug Larson
University of Arizona, Tucson, AZ
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Mohamad Azhar,
Mohamad Azhar
University of Arizona, Tucson, AZ
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Jonathan Vande Geest
Jonathan Vande Geest
University of Arizona, Tucson, AZ
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Darren Haskett
University of Arizona, Tucson, AZ
Marie Fouts
University of Arizona, Tucson, AZ
Urs Utzinger
University of Arizona, Tucson, AZ
Doug Larson
University of Arizona, Tucson, AZ
Mohamad Azhar
University of Arizona, Tucson, AZ
Jonathan Vande Geest
University of Arizona, Tucson, AZ
Paper No:
SBC2010-19635, pp. 725-726; 2 pages
Published Online:
July 15, 2013
Citation
Haskett, D, Fouts, M, Utzinger, U, Larson, D, Azhar, M, & Vande Geest, J. "The Effects of Angiotensin II Infusion on the Mechanical Response and Microstructural Organization of Mouse Aorta." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 725-726. ASME. https://doi.org/10.1115/SBC2010-19635
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