Interstitial flow is the convective transport of fluid through tissue extracellular matrix. This creeping fluid flow has been shown to be important in regulating the development, function, and pathology of tissues. Furthermore, interstitial flow has been shown to affect the morphology and migration of cells such as fibroblasts, cancer cells, endothelial cells, and mesenchymal stem cells (1). Chary and Jain used fluorescence recovery after photobleaching to directly observe fluid flow in the tissue interstitium and determined typical flow velocities are on the order of 0.1–2.0μm/s (2). Interstitial flow is particularly important in driving transport in tumor tissues, as neoplastic tissue is often characterized by increased interstitial pressure (3).
Skip Nav Destination
ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Interstitial Flow and Effects on Tumor Cell Migration
William Polacheck,
William Polacheck
Massachusetts Institute of Technology, Cambridge, MA
Search for other works by this author on:
Roger Kamm
Roger Kamm
Massachusetts Institute of Technology, Cambridge, MA
Search for other works by this author on:
William Polacheck
Massachusetts Institute of Technology, Cambridge, MA
Roger Kamm
Massachusetts Institute of Technology, Cambridge, MA
Paper No:
SBC2010-19446, pp. 719-720; 2 pages
Published Online:
July 15, 2013
Citation
Polacheck, W, & Kamm, R. "Interstitial Flow and Effects on Tumor Cell Migration." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 719-720. ASME. https://doi.org/10.1115/SBC2010-19446
Download citation file:
5
Views
Related Proceedings Papers
Related Articles
Bioactive Magnetoelastic Materials as Coatings for Implantable Biomaterials
J. Med. Devices (June,2009)
Pre-Clinical Evaluation of Direct Current Ablation for the Treatment of Benign Prostatic Hyperplasia
J. Med. Devices (June,2009)
Advances in Finite Element Simulations of Elastosonography for Breast Lesion Detection
J Biomech Eng (August,2011)
Related Chapters
Experimental Studies
Nanoparticles and Brain Tumor Treatment
Introduction
Nanoparticles and Brain Tumor Treatment
Conclusions
Nanoparticles and Brain Tumor Treatment